Maturation and Emigration of Single-Positive Thymocytes

نویسندگان

  • Xi Xu
  • Shusong Zhang
  • Pingping Li
  • Jin Lu
  • Qun Xuan
  • Qing Ge
چکیده

T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are "fully mature" and waiting to be exported at random or follow a "first-in-first-out" manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed.

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عنوان ژورنال:

دوره 2013  شماره 

صفحات  -

تاریخ انتشار 2013